I've been taking beta-blockers for over a quarter century.
In the 1970s I began experiencing terrible migraines, bad enough that eventually I would have to take something like Demerol for relief. That's, as they say, bad shit, and after a while I was getting to the point of having a killer headache every 10-14 days. At that rate, I'd be a junkie pretty soon.
My doctor, a cardiologist, told me about a new class of drugs, beta blockers, that were used for high blood pressure, and it had been serendipitously discovered that they also could prevent migraines. He put me on Inderal (propranolol); I was one of the first patients in the country to take it. Over a period of a couple of months, the migraines became less common, then vanished. So far as I could tell, the propranolol had no side effects at all.
About three years ago, I began having very alarming heart symptoms -- pounding, tachycardia, irregular heartbeat, etc.. My regular cardiologist told me I definitely needed open heart surgery (a valve job). Being a kid from a medical family, I immediately sought out a second opinion; my dad found me one of the best cardiologists in the country. His diagnosis was different, and the condition he diagnosed was treatable with strong beta blockers. He switched me to Toprol (metoprolol). It worked; the heart stuff, while gone, is no longer horribly annoying or scary.
Here's the kicker: it is not good for musical performance, at least not for me. Beta blockers cause you to get, well, slower is the best word I can come up with. They make me a little less on-the-ball. I call them my Stupid pills. Any improvement in clammy hands, etc., the beta blocker may bring is overshadowed by the step-down in mental acuity. Simply put, I hit more wrong notes under the influence of the blocker, and I learned the hard way not to take one an hour before a gig. If I take one at 11 am, though, it's calmed down enough that I can teach by 4:00 pm, or play a gig by 7:00 pm, particularly when I drink some coffee.
So that's my story, and I'm sticking to it.
Peace,
Paul