Apparently, the CR output level is adjusted via a digitally-controlled attenuator in the analog domain, so you don't have to fear losing resolution, the A/D always operates at full resolution.
The only optimization you have to do is run the CR output as hot as can be in order to maximize S/N ratio in the analog connection. As hot as can be means without entering into distortion.
I can't find any info regarding nominal and max level of C/R output on the MOTU website, so you'll have to figure out by yourself what range of output level suits you best and adjust the input attenuator on you power amp to produce suitable listening SPL.