Well Im very much trial and error in my design technique ,I dont tend to use a whole lot of maths to work things out ,tubecad/Se ampcad does come in very handy though ,does all the number crunching for you . Another very usefull program is Psud from Duncan designs . I find for high quality tube mics I dont often need much more than 20db or so of gain ,keeping the input transformer seperate from the pre works for me ,then you can select the most appropriate transformer as the need arrises . I did make a pre recently using an E88c ,low impedence triode ,but with quite high gain ,10k anode load ,cap coupled into a step down transformer ,so I can drive mic inputs if nessesary ,I added feedback from the transformer secondary through a pot into the lower end of the grid resistor, input impedence does vary a bit depending on source and the amount of feedback ,but does allow me to trim my input levels .I guess the best way to go is to have some idea of the amount of gain you need before starting on a design . Like with all tube gear its involves high voltages ,putting a high value resistor across the low end of the Ht supply to ground (220K ohm 2 watt ) is a good plan ,as this will bleed off any residual voltage on your smoothing caps within a few minutes of powering the unit down . Of course at some point you will need to test the voltages with the circuit powered ,make sure the multimeter has a good ground connection on the equipment ,a croc clip works best here. I also usually insulate the probe appart from the very tip ,with a piece of wire insulation ,just to lessen the chances of shorting something and sending sparks flying!
Old record players and reel to reel tape machines from the tube era make a great place to find cheap transformers and chokes for the experimenter , surplus pc powersupplies contain high voltage Electrolytic caps which are perfect for your power supply also. Many great books and articles from the old days are up online free to download nowadays ,The radio designers handbook is one you can find easily ,If you want something a bit more up to date any of the titles by Morgan Jones are full of great stuff..... have fun.