What do you need to feed the guitar signal to?
And what kind of guitar?
So you question should read as follows:
"Hi folks! I have a Fender Strat with single coil stock 8 k wound fender pickups.
I want to drive a Marshall Plexi 50 watt AND a Fender Twin, just like Trower.
How do I do this?"
or
"Hi folks! I have a Les Paul with Duncan 59's. I want to drive my Crate, and also send the output into the board for a Direct sound. What do I do?"
or
I have an Danelectro with active EMG's. I want to drive three marshalls, and three twins, what do I do?"
Each of these above scenarios will require a different solution.
If you have a magnificent instrument, and play professionally, including live, you will not want to upset one micron of that tone. Anytime you split, you will change something. Damage control. Thats the key.