As long as the switches are in the back panel like in that layout picture there probably won't be any problems. I've seen some attempts to put switches like that in the front panel with long leads going crisscross the circuit board and the results were not good.
I'm not a fan of that random grounding scheme that seems to be going on in that layout, but it often works well enough in guitar amps. I would at least take the negative side of the rectifier directly to the - of the reservoir cap (see attachment). Same can be done for the bias supply, but it most likely wont matter because there are no big ripple currents flowing there.
Here's a schematic to an amp that is similar to what you're planning to build, but it has a decent effects loop.
http://tube.ghr.fi/frieddan/frieddan.sch.svgI'll send you tonight when I get home gerber files for a pcb for that effects loop. The loop uses four BC547C transistors or any similar transistors can be used. The board has everything needed for an effects loop on it except you need to add a switch or a relay to switch the loop in and out.