I have found that plugging a guitar directly into a 2520 is amazing. Beyond that specific applicaiton, I like active DI's, which is what you need if you want to incorporate the input transformer. MOST of the "DI" inputs on boxes out there are simply 1/4" jacks that tap some part of a circuti that was never designed as a DI at all. the Brent Averill rack jobs are the worst offenders with this, as they use switching jacks that require coax run from the input transformer to the jack so not only is the "DI" worthless, but it kills the high end of the pre by adding a bunch of extra capacitence to the input which was never spec'd by the original designer. Averill is not the only company doing this... If you want a "real di" you should be thinking about an active solution in all cases, let alone if you want to use the input transformer. Plugging directly into a 325 line amp has worked for me in the past and also plugging directly into a quad eight opamp has had selected decent results but it all ultimately comes down to how the opamp and the instrument you are plugging into it play together. I would think if you wanted to run through the transformer, all that would go out the window and youd need an active input, which is probably the right way to do it in the first place. Dan kennedy's DI circuit is really nice for basses and guitars.
dave