Well,
I work with that FR4 stuff regularly (1/8" thick specifically). It's not as bad as everyone is making it out to be, though cutting it can leave one heck of a mess if you don't have a vaccum attached to whatever you're cutting it with. And that stuff isn't exactly the best to be breathing in either (wear at least a paper mask and some eye protection). Use a table saw. Cutting it requires using the same type of saw blade that's used for cutting melamine countertops.
But honestly, if you know a cabinet maker, that's your best bet (where I go actually). Odds are they've already got the right blade for the saw. And I'd stay away from using a band saw. While you might lose a bit less material, the cuts just never come out as nice as with a table saw. And it's much faster to boot.
Then, if this is more of a one-off, you can just do a paper template (did someone say template??) in your favorite pc board layout program, and tape it to the top of a stack of boards (provided they're identical, of course). Tape the lot together tightly with wide painter's tape to keep them from moving around. Then, with a new titanium drill bit, you can pretty easily go through about 5-6 1/8" boards at once which cuts down your drill time. I've gotten as many as 100 turret boards with about 70-80 holes each, without having to change bits to avoid tearout.
Between those two steps, it shouldn't take more than a couple of hours for 20 identical boards... If they're unique, a bit longer....
If you're looking for CNC level precision, well then that's another story entirely. But with that process, a little patience and a good eye, you can get pretty close. I can usually get it so the turrets line up to a stratght edge by eyeballing the whole thing...
But, if you really want someone to do it, PM me.