For my new interface, I'll be looking at the Motu 828-ES ... only if the vendor lets me 'trial' a demo unit 'at home' first!
I like the 'ESI Sabre' feature and I'm OK with the USB 2.0 [usb 3.0 'downwards compatible'] as I only really do about 6chns of I-O simultaneously these days in my 'studio' [lounge and dining rooms
] and generally only at fs 48Khz
For PC, I like the USB3.0 functionality, but I'm not aware of any usb 3.0 audio interfaces that actually demonstrate any advantage over USB 2.0, in terms of throughput and stability of use.
USB3.0 is stonkingly fast, responsive and stable with my 'data drives' ... I use an external 4x sata3 HDD enclosure with USB3.0 as 'backup' off my 'WinServer_2009 storage system server' and it absolutely 'kicks a**' in use.
Not bad for a circa 2007 box [was my DAW for many years!] with a usb3.0 pcie add-in card [$20]. The file server [quad Pentium!] also has 6x internal sata2 HDD for 'front line' storage which is amazingly fast across my own home network, for a number of years now.
I use 'Goodsync file system synchronisation' app .. super, super awesome for version/control archiving etc on huge network archives.
...
Thunderbolt and the more modern stable of Mac interfaces are great on paper, [from my PC perspective] but not well supported in the PC world, as far as I know.
[could easily be a case of me being out-of-date!]
For serious multi-channel throughput at higher sample rates, usb2.0 is suspect in my book - but I could be convinced with a solid piece of kit.
At present, I remain a fire-wire and/or Motu pci-e user; of course both are quite old hat but still work on my systems, particularly when doing high channel counts .... the Motu 2408Mk3 has no issues at all with all 24 I-O simultanous at 48KHz ... even in Win10
Lol, Win10 just now 'flipped me the bird' with the .. 'blue screen' .. of 'unrequisitioned restart permissioning' [bsod] feature ... sigh ....