by series, I think you refer to a pultec/passive topology...frequency selective networks shunt (subtract/dump to ground) more or less of there respective spectral band and a make-up amp corrects for the loss imposed by the passive eq network (when it is set to flat)
please do us a favor and read through the METAs, tons of good info out there
by parallel you are talking 'bout an active topology like the S800, calrec, sontec, w492, 553, etc..(?)where frequency selective network is in the feedback path of an op-amp negative fb=cut ;positive fb=boost
can all be done with more or fewer tubes. silicon is cheaper and easier to implement for many functions.
do you want tubes to do all the magical things like 2nd harmonics, soft clipping, warmth?:
build a couple 1 bottles, milas, g9s, whatevers, omit the mic step-up transformer...build 4 1-bottles and cascade 2 pairs for extra goodness...