Ah, the joy of 60's British electronics.
This may be redundant but
1 - Tubes ain't what they used to be. VOX designed their amps right to the max and most modern output tubes will wilt under the voltage/current. Most US households also run 120 VAC and not the 115 VAC these were designed around. Several manufacturers make heavy-duty EL34's that will handle the load.
Just remember - VOX amps "eat" output tubes
2 - The transformers used in British amps were not as rugged as the ones in US amps. I've never had a Fender catch fire but I've had a Marshall 100 do just that when the Output Transformer melted. The systemic heat in VOX amps broke down the insulation. So....
3 - Get an aftermarket 100 Watt EL34 output transformer that will handle 100 watts without running on the bleeding edge. There appears to be a new(?) company - US Classics - which is picking up where Classictone closed shop. (Very coincidentally the US Classics are made in Chicago with paper bobbins just like Classictone - but priced higher)
You might want to add a PC internal fan to pull the heat out.
4 - VOX usually has almost as many versions as actual production numbers - most without documentation. You've also discovered that just because it fits, a 12AX7 doesn't always work for a 12AU7. Not every guitar amp owner can read a schematic or tube list. "What do you mean it uses different tubes than my Fender?" The fact you could read the schematic and ascertain that maybe there was an issue with the PI tube put you way ahead of the game.
The AC-100 was VOX's response to the "arms race" for more powerful amplifiers. Like the mutant Fender 180's I wonder if VOX just pushed it a little too hard. It seems to me the esthetics of the head were more important than reducing the internal heat. I don't think enough engineering went in to doubling the output of the AC-50
Every VOX I've worked on was "ridden hard and put away wet." It often was more like restoring a vintage car than repairing an amp.
Hope your repairs last