Here's a thing you can try.
Take the mains lead out of the unit and measure resistance between Neutral and Earth on the mains inlet of the equipment.
There shouldn't be anything, it should be open circuit, infinity ohms.
If there is, this can induce hum through your entire system.
The Neutral is usually connected to earth where it enters the building, though in rural Ireland this might actually be anywhere on the planet.
But if you connect Earth to Neutral locally by accident, you could create a massive Earth Loop that will confuse you til you die.
The Isolation transformer you mentioned should actually make a difference if this is the case, either fitted to the offending unit or the whole system.
Edit: In fact given your circumstances I think I would get one for the studio anyway.
It could also be that your "Earth" connection is a pole hammered into the ground outside your house.
Sometimes watering it can help so I've heard, if it isn't boggy enough already.