You need to look at the power supply electrolytic caps as well as the audio coupling caps; not so much the PSU reservoir caps, but the low-value caps used around the regulators. When these go out of spec, it can affect the voltage rail stability, and hence the audio performance.
Audio coupling caps and some of their problems have already been dealt with in previous answers.
I don't recall the exact circuit topology of the power distribution of RED2, but if it's individual electrolytic decoupling of each chip, when the decoupling caps go dry, the EQ circuit can become a tunable oscillator

. This is a disturbing experience the first time around, but once learned, power caps are a go-to first check on any Neve-type of circuit.
Regarding RED3, I don't know what Focusrite did to it after I left in mid-1993, but I do recall most of the circuitry in the prototype designs.
If I were faced with the RED3 problems you have, I would make a note of how long it takes for the crackling and simmering to start.
Then check power supply voltages to see if anything is radically out-of-spec; repair if required.
Re-test to see if the crackling returns.
After that, check electrolytic cap values and ESR measurements throughout the unit. Replace any duff caps, test again. When does the crackling start?
With caps attended to, it's time to move on to other components.