Well - don't quote me on this - but i would think crosstalk would be a bigger problem on higher level signals like line level.
It may be an issue if you have a really hot signal adjacent to a really low signal....but other than that?
Edit: i'm assuming you are using individual screened pairs in the 8 way cable - or even if you use ribbon d--subs - if the pinout is correct, each hot/cold pair should have a screen either side in the ribbon.
I've seen many edac/harting pinouts on pro consoles that have a common screen and hot next to adjacent hot pinouts without any noticeable crosstalk at mic and line levels!