R16 will have only op-amp input bias current flowing in it. But the object in an inverting amplifier is to hold the + input at virtual ground (1/2 Vcc). Using such a high value opens the door to parasitic oscillation or instability due to a few pF of stray capacitance. Sometimes a resistance equal to that in the negative feedback loop is used to partially compensate for DC bias current offset in circuits requiring high DC accuracy. But, even then, a wise circuit designer will bypass it to avoid creating the aforementioned sensitive node at the + input. I'd use 1 k-ohms or eliminate the resistor altogether.