i think that first you need to identify wich regulator is causing latch-up. the 12V regulators are cascaded after the 15V regulators.
you need to measure which voltages are wrong when latch up is present.
in my case I had latch up problem with the 15 regulators, and fixed that by adding capacitor and diodes on the back of the pcb. but now i also have problem with the +12v regulator, so i try to fix that or change to another brand.
about the unbalanced connection, probably if in your mixer inserts connection the negative input is connected to ground, this causes problem to the IC input/output stage, which maybe the transformers don't suffer. but you can easily try and see.
you need to measure which voltages are wrong when latch up is present.
in my case I had latch up problem with the 15 regulators, and fixed that by adding capacitor and diodes on the back of the pcb. but now i also have problem with the +12v regulator, so i try to fix that or change to another brand.
about the unbalanced connection, probably if in your mixer inserts connection the negative input is connected to ground, this causes problem to the IC input/output stage, which maybe the transformers don't suffer. but you can easily try and see.