No two tubes are the same no matter the type, so i re bias them always. For example Universal Audio strongly suggests re-biasing tubes after replacing tubes in their units, you can check UA LA-610 manual for example.
In my experience almost every time someone talks about particular sonic imprint of certain unit there is a fault, or low end bump, high end cut, distinct THD character. This can be achieved with an EQ, or by tweaking of the circuit. None of which cost more than few bucks. But yes, it can be done by spending a lot more money not knowing what you've done at the end.