The GL850G is NOT an isolator. It is just a hub. A USB 2.0 Hub. Nothing wrong with using it, it is comparable to the chinese FE1.1. But it is easiest to buy an existing hub and hack it, over building one's own.
There is currently no USB 2.0 high speed capable USB isolator (there was one for a while but it was EOL'ed years ago). It looked like this:
VL811 is a USB 3.0 Hub, ICE08 is the USB 2.0 Isolator.
USB 3.0 is capacitively isolated inherently and is as such easily isolated, HOWEVER as USB 3.0 needs USB2.0 high speed working to negotiate USB3.0 capabilities, USB 3.0 isolation does not work without USB 2.0 high speed isolation.
This is a fully tested and working design to isolate USB1.1, 2.0 & 3.0. The isolated power supply is a simple flyback design, 5V in 5V out.
Thor