Oh yeah better check that twice. Relays are polar. I remember this seriously messed Stefan and me up one time working on the Q when need arose to mirror the entire master board, and all things were considered and no problem - EXCEPT the relays (that took an entire day to figure it out..."but I don't understand, we had it working...") Try to read THAT one out of a spectragraph
Anyway, at this point, might I flag DANGER WILL ROBINSON. Let's take a step back and NOT slap everything onto a PC board together just yet, with all these ideas we are having you are heading for WORKING HELL.
Trust me on this one. You go through 20 or so entire new PC board designs and nuts in the process, especially when you have to keep making new entire boards when you decide to change something small.
What I'd suggest is this: Floating islands to begin with. Design the input and FET section down to C14 separately, the output section and detector separately, and let me send you a CnB board that's ready-made and tested. I can totally understand the itching to design the heck out of this bugger, but it's a lot easier in the workflow to get your function blocks made first, and then just needing to slap them together on a single board.
Sorry for the rant but I've been there.